Preface
In the world of science, nothing invigorates the mind so much as to watch a concept develop from some
small seed of discovery to a universally applicable technology. In the last four decades,
chromatography, the once mysterious and very crude technique, has grown into a very sophisticated and
reliable separation methodology. Over the last decade, the application of the accumulated knowledge to
the once esoteric field of chiral separations has made impressive advances particularly in the last three
years. The chromatography of enantiomers has required the preparation of highly structured phases,
which had to be designed to have a direct bearing on the nature and the chemistry of the materials to be
separated. New terms had to be introduced and defined, such as three point interaction and inclusion
complexation to describe some of the new interactive mechanisms that were invoked. As will be
apparent from this book, however, the basic chromatography terms and the physical chemical principles
that determine that a chromatographic separation is possible remain the same. In dealing
comprehensively with the subject of chiral chromatography, a significant amount of theory must be
included, but we have tried to present this in a manner that explains the interactions that takes place and
provides a rational direction that can be taken to solve practical problems.
Having been involved in chromatography for many years (our combined experience extending over
three quarters of a century) we find it gratifying to see the very substantial increases in successful chiral
separations that are currently published in the field. Starting from the pioneering work of Gil-Av (1966)
and Bayer (1974) followed by that of Okamato and Pirkle and culminating with the recent, highly
innovative phases, introduced by Armstrong, chiral chromatography has now reached a high degree of
sophistication. The creation of the cyclodextrin phases and the introduction of the macrolytic antibiotics
by Armstrong has brought new incentives to the field and many new areas of application.
This book has been written to serve both the novice in the field and the experienced chromatographer.
In addition to giving detailed information on chiral separations, it also discusses the principles involved
in chiral selectivity and, for those new to the technique, describes the fundamentals of a
chromatographic separation and the essential apparatus needed to carry it out. To make the book as
complete as possible we have included chapters on preparative chiral chromatography and some basic
请点击此处下载
收藏
