This course is aimed at those who are already familiar with using NMR on a
day-to-day basis, but who wish to deepen their understanding of how NMR
experiments work and the theory behind them. It will be assumed that you are
familiar with the concepts of chemical shifts and couplings, and are used to
interpreting proton and 13C spectra. It will also be assumed that you have at
least come across simple two-dimensional spectra such as COSY and HMQC
and perhaps may have used such spectra in the course of your work. Similarly,
some familiarity with the nuclear Overhauser effect (NOE) will be assumed.
That NMR is a useful for chemists will be taken as self evident.
This course will always use the same approach. We will first start with
something familiar – such as multiplets we commonly see in proton NMR
spectra – and then go deeper into the explanation behind this, introducing
along the way new ideas and new concepts. In this way the new things that
we are learning are always rooted in the familiar, and we should always be
able to see why we are doing something.
In NMR there is no escape from the plain fact that to understand all but
the simplest experiments we need to use quantum mechanics. Luckily for us,
the quantum mechanics we need for NMR is really rather simple, and if we
are prepared to take it on trust, we will find that we can make quantum mechanical
calculations simply by applying a set of rules. Also, the quantum
mechanical tools we will use are quite intuitive and many of the calculations
can be imagined in a very physical way. So, although we will be using quantum
mechanical ideas, we will not be using any heavy-duty theory. It is not
necessary to have studied quantum mechanics at anything more than the most
elementary level.
Inevitably, we will have to use some mathematics in our description of
NMR. However, the level of mathematics we need is quite low and should not
present any problems for a science graduate. Occasionally we will use a few
ideas from calculus, but even then it is not essential to understand this in great
detail.
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