色谱书籍推荐：Chromatography and Separation Science 色谱分离科学
For more than 25 years, I led a group in Analytical R&D in a major
pharmaceutical company (Novartis), and also taught a course on chemical
separations at Pace University. I had the pleasure of succeeding Lloyd Snyder,
who had taught this course before me. We used Karger, Snyder, and Horvath’s
An Introduction to Separation Science (Wiley) as a text for this course. I also
taught graduate courses on separations and advanced biochemical analysis at
Rutgers University and a course on modern methods of chemical analysis at
Polytechnic University. I found that I had to use at least a dozen books
to convey the subject of chromatography and separation science to the
students. All of those books and more are adequately referenced in this
text to enable the reader to seek more details. The books that were found
especially useful, besides the one mentioned above, were Pecosk, Shields,
Cairns, and McWilliam’s Modern Chemical Analysis (Wiley), Stahl’s, Thin-
Layer Chromatography (Springer-Verlag), Snyder and Kirkland’s Introduction
to Modern Liquid Chromatography (Wiley), Poole and Poole’s Chromatography
Today (Elsevier), McNair and Miller’s Basic Gas Chromatography
(Wiley), Miller’s Separation Methods in Chemical Analysis (Wiley), Giddings’s
Dynamics of Chromatography (Marcel Dekker) and Unified Separation
Science (Wiley), and books by me, entitled Selectivity and Detectability
Optimizations in HPLC (Wiley), Trace and Ultratrace Analysis by HPLC
(Wiley), and Chiral Separations by Chromatography (Oxford). I am indebted
to the valuable contributions made by these scientists.
After several years of dealing with this number of books, it occurred to
me to plan a text that would cover this subject of chromatography and
separation science in a concise manner and avoid burdening the reader with
a lot of details and mathematical equations. This book is designed for
students and separation scientists who are not averse to learning a fewequations dealing with physicochemical processes that influence chromatography
and separations. The main objectives of this book are as follows:
. Provide basic information on chromatography and separation science.
. Describe the relationship between these important fields.
. Cover how simple extraction or partition processes provide the basis
for development of chromatography and separation science.
. Describe the role of chromatography and separation science in various
fields.
. Discuss the role of chromatography and separation science in
development of new methodology.
. Cover new evolving methods and show how to select an optimum
method.
Separation can be defined as an operation in which a mixture is divided
into at least two fractions having different composition, molecular mass, or
stereochemical structure. An actual separation is usually achieved by physical
process, although chemical reactions may occasionally be involved in this
process. It is important to learn the fundamental physical and chemical
phenomena involved in the achievement of separations, as well as those with
the development and application of various separation processes. This
continually evolving discipline is called separation science.
Chromatography derives its name from chroma and graphy, meaning
color writing. It is essentially a physical method of separation in which
components to be separated are distributed between two phases.
Chromatography is a powerful technique concerned with separations of a
large variety of complex compounds. The contributions of chromatography
to various scientific disciplines and the benefits that chromatography provide
to mankind are unparalelled. For example, the progress made in the
biological sciences such as biotechnology, clinical pharmacology/therapeutics,
and toxicology provides an excellent testimony to the contributions of
chromatography. Examples from these and other fields are included
throughout this textbook.
This book will provide the necessary information to improve the
comprehension of separation science. It will show how chromatography
relates to separation science and describe how simple separation methods
have led to highly useful chromatographic techniques that provide high
resolution (Chapters 1 and 2). To provide a better understanding of transport
phenomena and thermodynamics, an elementary discussion is included in
Chapters 3 to 5.
The discussion on chromatography should help improve the understanding
of the principles involved in various modes of chromatography such
as paper chromatography, thin-layer chromatography, gas chromatography,
and high-pressure liquid chromatography (Chapters 6 to 10).
This book relates simple separation techniques—such as extraction—to
chromatography. And it lets us see how chromatography in turn relates to
capillary electrophoresis or field flow fractionation (Chapter 11).I believe that both theory and many interesting applications of various
chromatographic and separation techniques included in this book will be
found useful by the readers.
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