《Drug Discovery in Cancer Epigenetics》Elsevier(2016)

书籍推荐 · 发表于 2019-2-11 16:50:29

CHAPTER OUTLINE
1.1 Introduction .....................................................................................................................................4
1.2 Basic Epigenetic Mechanisms ...........................................................................................................6
1.2.1 DNA Methylation .......................................................................................................... 7
1.2.2 DNA Demethylation ...................................................................................................... 8
1.2.3 Histone Modifications ................................................................................................... 8
1.2.3.1 Histone Acetylation and Deacetylation.......................................................................8
1.2.3.2 Histone Phosphorylation .........................................................................................10
1.2.3.3 Histone Methylation and Demethylation ..................................................................10
1.2.3.4 Chromatin-Remodeling Complexes and Histone Variants .........................................11
1.2.4 Noncoding RNAs ........................................................................................................ 11
1.3 Epigenetic (Re)Programming........................................................................................................... 12
1.3.1 Epigenetic Asymmetry in the Zygote............................................................................. 12
1.3.2 Reprogramming in the Germline .................................................................................. 14
1.3.3 Induced Pluripotency.................................................................................................. 14
1.4 Genomic Imprinting as a Model of Epigenetic Silencing ................................................................... 15
1.5 Dosage Compensation in Mammals ................................................................................................. 17
1.6 PEV in Drosophila .......................................................................................................................... 19
1.7 Transgenerational and Intergenerational Epigenetic Inheritance ....................................................... 20
1.8 Epigenetics and Disease................................................................................................................. 23
1.8.1 Selected Monogenetic Diseases ................................................................................... 23
1.8.2 Selected Neurodegenerative Diseases........................................................................... 26
1.8.3 Selected Autoimmune Diseases ................................................................................... 27
References .......................................................................................................................................... 28……

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