Chapter 1 Introduction: General Aspects of the Chemical Biology of
Glycoproteins 1
Patrick K. Chaffey, Xiaoyang Guan, Lai-Xi Wang and
Zhongping Tan
1.1 Introduction 1
1.1.1 Complexity of Protein Glycosylation 2
1.1.2 Strategies and Methods to Study Protein
Glycosylation 3
1.2 Chemical Biology of Glycoproteins 5
1.2.1 Types of Protein Glycosylation 5
1.2.2 Biosynthesis of Glycoproteins 7
1.2.3 Structural and Functional Consequences of
Protein Glycosylation 8
1.2.4 Methods to Prepare Homogeneous
Glycopeptides and Glycoproteins 10
1.2.5 Chemical Glycobiology and Applications 11
1.3 Conclusion 12
References 13
Chapter 2 Chemical Biology of Protein N-Glycosylation 20
Chao Li and Lai-Xi Wang
2.1 Introduction 20
2.2 Biosynthesis and Intracellular Functions of
N-Glycans of Glycoproteins 21
2.3 Inhibitors of Glycan-Processing Enzymes for
Controlling Protein N-Glycosylation 23