The contents of this book are divided into three parts. The first part is dedicated to the battery of the most modern
molecul ar biology techniques and a historical perspective of the low-throughput methods. In order to keep pace with recent
developments, the majority of the chapters from the previous editions have been either merged into a few chapters or
omitted altogether, while being mentioned and fully referenced in the updated chapters. A large number of chapters
pertaining to high-throughput molecular diagnostic approaches, for ex ample, microarrays, next-generation sequencing,
mass spectrometry, next-generation sequencing cytogenomics, etc., have been included. The remaining chapters fiom the
previous editions have been comprehensively updated to include not only technology innovations but also novel diagnostic
applications. This resulted in the book being completely revamped with over half of its content being new compilations.
The second part attempts to integrate previously analyzed technology with different aspects of molecul ar diagnostics,
such as pharmacogenomics, molecular forensics and victim identification in mass disasters, and preimplantation genetic
diagnosis, while new emerging disciplines, such as nutrigenomics, genome informatics, and genomic databases, have been
included. Finally, various everyday issues in a diagnostic laboratory, from genetic counseling to related ethical and
psychological issues to safety and quality management, are discussed in the third and final part of the book. As with the
previous two editions, we fel that the inclusion of the latter issues in this reference book has great relevance to our society.