The field of DNA repair is enjoying a remarkable time of interest with the recent Nobel Prize in Chemistry
awarded to pioneering scientists in “Mechanistic Studies in DNA Repair”: Thomas Lindahl, Paul
Modrich, and Aziz Sancar. In addition, the use of specific DNA repair inhibitors in cancer clinical trials
is rapidly expanding, and so is the development of additional molecules that are either being tested or
are rapidly moving through the preclinical developmental stage. With precision medicine aiding in our
selection of patient and proper chemotherapeutic agent, scientists and clinicians are gathering a better
understanding of the DNA repair deficiencies that a tumor possesses and attacking its so-called Achilles
Heel. However, this recent focus has not decreased the basic science interest in pursuing research in
the still-unknown mechanisms involving various DNA repair pathways. Particularly interesting is the
continuing discovery of interactions between the various pathways that will afford opportunities for
future translational and clinical efforts. We have tried to include the most current information possible
in the contents, however, as the field is rapidly accelerating we acknowledge that some information will
not be current by publication time, particularly the information concerning specific inhibitor molecules
and clinical or preclinical successes and failures. In spite of this, we anticipate that this book will be
a strong reference for those who want to delve into DNA repair and understand pathways, their basic
mechanisms, the relevance of DNA repair to human cancer. This background information will not be
eclipsed by future discoveries, but serve as the foundation for future studies. With this being the second
edition, we are impressed that we already had so much to update in the field of DNA repair and translational
cancer research. This is a testimony to the hard work of the contributors’ and scientists in this
exciting and expanding field. In the end, the real purpose of this book is to try and give an overview
of where those who study DNA repair stand in understanding and development agents to fight against
cancer. This area has been highly underappreciated and is finally gaining the recognition it so richly
deserves.
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