《Biomolecular Kinetics：A Step-by-Sep Guide》Clive R. Bagshaw 著
Chemical kinetics of biological systems has a long history. Brewing is often
cited as an early example of applied biochemistry and timing is clearly a key
part of the fermentation process to generate the desired alcohol concentration.
But even in terms of modern biochemical investigations, kinetic measurements
represent a long-standing methodology. Many of the key concepts were derived
more than a century ago [1]. For these reasons and their continued under-pinning
role in biochemical assays, the fundamentals of steady-state enzyme kinetics are
introduced in most first-year undergraduate biochemistry courses, including
the practical measurement of enzyme activity. In parallel, the principles of firstand
second-order reactions are taught in first-year supplementary chemistry
courses, but often with few biochemical examples. In subsequent years, the
teaching of biomolecular kinetics has been squeezed out of the curriculum by the
incredible expansion in knowledge across the biochemical sciences that must be
accommodated within a three- or four-year period. Unfortunately, this has led to
a situation where kinetics is often seen as “old hat,” and any later course option
with “kinetics” in the title is likely to be met with low registration. Actually, this is
not a new phenomenon. More than 30 years ago, Engel [2] likened the attitude
toward kinetics being on par with Latin and cold showers: “c ...
