Information theory applied to chromatographic fingerprint of herbal medicine for quality control
At present, the construction of chromatographic fingerprints plays an important role in the quality control of complex
herbal medicines. In this work, information theory was applied to obtain chromatographic fingerprints with good
performance. Moreover, according to the characteristics of the chromatographic fingerprints obtained, some modifications of
the calculation of the information content were conducted. In comparison with the information content from several
chromatographic fingerprints obtained, reliable chromatographic fingerprints with a high separation degree and uniform
concentration distribution of chemical components could be determined. The successful application of information theory
with modification to simulated chromatographic fingerprints together with real herbal medicines such as Rhizoma
chuanxiong and Ginkgo biloba from different sources demonstrated clearly that the proposed method to determine
chromatographic fingerprints was reasonable and reliable and it was user-friendly. Chromatographic fingerprints determined
with high separation degrees and uniform concentration distribution of chemical ingredients might also chemically represent
characteristic components of herbal medicines for quality control.
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