书籍名称 :癌症方面巨作《Cancer Genetics and Genomics for Personalized Medicine》
编著人员 : Il-Jin Kim
出版单位 : 隐藏内容
出版时间 : 2017
涉及领域: 医药书籍 » 医疗书籍
推荐等级: ★★★★
癌症方面巨作《Cancer Genetics and Genomics for Personalized Medicine》
Il-Jin Kim是加州大学旧金山分校胸部肿瘤学计划的首席研究员和应用基因组学主任。他的工作重点是鉴定各种类型人类癌症的新型治疗靶点和诊断标志物。Kim博士使用最先进的技术研究人类癌症,包括他与团队共同开发的新一代测序(NGS)和系统遗传工具。他开发了几种创新的微阵列,并开创了高通量突变筛选的新方法,并拥有多项专利。他发表了70多篇论文,包括科学与自然通讯。他还获得了美国癌症研究协会颁发的三项奖项,用于开发创新的遗传和诊断分析。
This book covers almost all fields of cancer genetics and genomics for personalized medicine. Surely, the one-fits-all approach does not work anymore for disease treatment. Targeted therapy or precision medicine or personalized medicine is becoming a standard for many disease treatments including cancer. However, how much do we know about the personalized medicine approach This book will help undergraduate/graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.
1 Personalized Medicine for Cancer: Introduction and
Overview of the Book 1
Il-Jin Kim and David Jablons
1.1 Changing the Treatment Paradigm for Cancer 1
1.2 Companion Diagnostics and New Sequencing
Technologies 3
1.3 Early Detection of Cancer and Tumor
Recurrence Monitoring: Circulating Tumor
Cell (CTC) and Circulating Tumor DNA
(ctDNA) 5
1.4 Cancer Animal (Mouse) Models and
Microenvironment for Personalized Medicine 6
1.5 Personalized Immunotherapy 7
1.6 Hereditary Cancer Syndromes and Potential
Treatment 7
1.7 Future Directions 8
2 Personalized Medicine in Lung Cancer 15
Daniela Morales-Espinosa, Silvia Garc′ıa-Rom′ an,
and Rafael Rosell
2.1 Introduction 15
2.1.1 Predictive Models 16
2.1.2 The Molecular Diagnostics Approach 17
2.1.3 Conventional Chemotherapy 19
2.1.3.1 Cisplatin 19
2.1.3.2 Pemetrexed