Contents
Chapter1 Bioanalytical Assays in a Drug Discovery Environment 1
Walter A. Korfmacher, Ph.D.
Chapter2 Drug Metabolism In Vitro and In Vivo Results: How
do these Data Support Drug Discovery? 35
Thomas N. Thompson, Ph.D.
Chapter3 High Throughput Strategies for In Vitro
ADME Assays: How Fast Can We Go? 83
Daniel B. Kassel, Ph.D.
Chapter4 Matrix Effects: Causes and Solutions 103
Hong Mei, Ph.D.
Chapter5 Direct Plasma Analysis Systems 151
Yunsheng Hsieh, Ph.D.
Chapter6 Acyl Glucuronides: Assays and Issues 175
Sam Wainhaus, Ph.D.
Chapter7 Utilizing Higher Mass Resolution in Quantitative Assays 203
Xiaoying Xu, Ph.D.
Chapter8 Special Requirements for Metabolite Characterization 229
Kathleen Cox, Ph.D.
Chapter9 APPI: A New Ionization Source for LC and MS/MS
Assays 253
Yunsheng Hsieh, Ph.D.
Chapter 10 Q Trap MS: A New Tool for Metabolite Identification 277
Ge′rard Hopfgartner, Ph.D. and Manfred Zell
Chapter 11 MS Imaging: New Technology Provides
New Opportunities 305
Michelle L. Reyzer, Ph.D. and Richard M. Caprioli, Ph.D.
Chapter 12 Understanding the Role and Potential of Infusion
Nanoelectrospray Ionization for Pharmaceutical
Bioanalysis 329
Bradley L. Ackermann, Ph.D. and
Jean-Marie Dethy, MSc.
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