1 Structure and Function of the Stressosome Signalling Hub................ 1
Jan Pané-Farré, Maureen B. Quin, Richard J. Lewis,
and Jon Marles-Wright
2 The Canonical Inflammasome: A Macromolecular
Complex Driving Inflammation.............................................................. 43
Tom P. Monie
3 The Ferritin Superfamily........................................................................ 75
Alejandro Yévenes
4 Antibody Recognition of Immunodominant Vaccinia
Virus Envelope Proteins.......................................................................... 103
Dirk M. Zajonc
5 The Peroxiredoxin Family: An Unfolding Story................................... 127
Zhenbo Cao and John Gordon Lindsay
6 α2-Macroglobulins: Structure and Function.......................................... 149
Irene Garcia-Ferrer, Aniebrys Marrero, F. Xavier Gomis-Rüth,
and Theodoros Goulas
7 The Structure and Function of the PRMT5:MEP50 Complex............ 185
Stephen Antonysamy
8 Symmetry-Directed Design of Protein Cages and Protein
Lattices and Their Applications.............................................................. 195
Aaron Sciore and E. Neil G. Marsh
9 Structure and Function of RNA Polymerases
and the Transcription Machineries........................................................ 225
Joachim Griesenbeck, Herbert Tschochner, and Dina Grohmann
10 Dihydrodipicolinate Synthase: Structure, Dynamics,
Function, and Evolution.......................................................................... 271
F. Grant Pearce, André O. Hudson, Kerry Loomes,
and Renwick C.J. Dobson
11 “Pyruvate Carboxylase, Structure and Function”................................ 291
Mikel Valle
12 Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction............... 323
Henry C. Nguyen, Wei Wang, and Yong Xiong
13 The Ccr4-Not Complex: Architecture and Structural Insights........... 349
Martine A. Collart and Olesya O. Panasenko
14 Higher-Order Structure in Bacterial VapBC
Toxin-Antitoxin Complexes..................................................................... 381
Kirstine L. Bendtsen and Ditlev E. Brodersen
15 D-Glyceraldehyde-3-Phosphate Dehydrogenase
Structure and Function........................................................................... 413
Michael R. White and Elsa D. Garcin
16 Protein Complexes in the Nucleus: The Control
of Chromosome Segregation................................................................... 455
Victor M. Bolanos-Garcia
17 GroEL and the GroEL-GroES Complex............................................... 483
Noriyuki Ishii
18 The Aminoacyl-tRNA Synthetase Complex........................................... 505
Marc Mirande
19 The Pyruvate Dehydrogenase Complex and Related
Assemblies in Health and Disease........................................................... 523
Olwyn Byron and John Gordon Lindsay
20 Structure and Assembly of Clathrin Cages........................................... 551
Mary Halebian, Kyle Morris, and Corinne Smith
Index.................................................................................................................. 569
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