《Color Atlas of Genetics》4th Edition Eberhard Passarge著
From reviews of previous editions: A remarkable achievement concise but informativeNo geneticist or physician interested in genetic diseases should be without a copy -- American Journal of Medical Genetics Ever since the international Human Genome Project achieved its extraordinary goal of sequencing and mapping the entire human genomewith far-reaching implications for understanding the causes and diagnosis of human genetic disordersprogress in the field has been rapid. In the fourth edition of the bestselling Color Atlas of Genetics, readers will get a full overview of the field today, with an emphasis on the interface between fundamental principles and practical applications in medicine. The book utilizes the signature Flexibook format designed for easy visual learning and retention, and is invaluable for students, clinicians, and scientists interested in keeping current in this fast-moving area. New topics in the fully revised fourth edition of this highly praised atlas: * Genetic signaling pathways involved in genetic disorders* DNA repair systems* Genomic disorders and genome-wide association studies* Cancer genomes* Ciliopathies, neurocristopathies, and other groups of causally related disorders* Epigenetic changes in certain disorders* Illustrated outline of human evolution With almost 200 stunning color plates concisely explained on facing pages, and including useful tables of data, a glossary of terms, key references, and online resources, this book makes every concept clear and accessible. It is an excellent introduction to genetics and basic genomics for students of medicine and biology, as well as an ideal teaching aid and refresher for investigators in any field of medicine or science.
Introduction 1
Fundamentals 25
Prologue 26
Molecular Basis of Genetics 32
Analysis of DNA 62
Variability of DNA 78
Processing of DNA 86
Eukaryotic Cells 94
Formal Genetics 114
Chromosomes 144
Regulation of Gene Function 174
Epigenetic Modifications 190
Genetic Signal Pathways 198
Genes in Embryonic Development 208
Genomics 217
Genetics and Medicine 247
Imbalanced Homeostasis 248
Metabolic Disorders 264
Immune System 284
Origins of Cancer 300
Impaired Cell and Tissue Structure 322
Hemoglobin Disorders 344
Sex Determination and Differentiation 356
Atypical Patterns of Genetic Transmission 364
Sensory Perception 370
Karyotype-Phenotype Relationship 382
A Brief Guide to Genetic Diagnosis 388
Morbid Anatomy of the Human Genome 398
Chromosomal Locations—Alphabetical List 404
Appendix—Supplementary Data 409
Glossary 425
Picture Credits 451
Index
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