NMR Experiments for Assignment

仪器资料 · 发表于 2018-7-25 15:22:12

NMR Experiments for Assignment
Dr Michael Thrippleton

Introduction
Selecting experiments for assignment:
1. what type of information do you want?
• chemical shifts
• coupling constants
• correlations
2. what type of spectrum do you want?
• quick
• sensitive
• high-resolution
• information-rich
3. choose/modify/invent an experiment

1. 1D Carbon NMR
• 1D carbon spectrum
• 1D carbon spectrum (proton decoupled)*
• APT*
• DEPT*
2. 2D proton NMR
• COSY
• DQF COSY*
• long-range COSY
• TOCSY
3. 2D carbon NMR
• INADEQUATE
4. 2D proton-carbon NMR
• HMQC
• HMQC (proton-decoupled)*
• multiplicity-edited HSQC*
• HMBC*
• HSQC
• HETCOR
5. The rest
• 1D analogues
• macromolecules, solids, multinuclear

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