质谱分析中的同位素介绍－英文

仪器资料 · 发表于 2018-11-26 20:08:47

质谱分析中的同位素介绍－英文
As mass spectrometrists we need to understand that isotopes are part of the data that we collect every day in our labs. Even if we are saving our data
in centroid mode or running at low resolution isotopes have a big impact on our mass spectrometry data. In electrospray, quadrupole mass
spectrometry and in every other type of mass spectrometry isotopic displays contain a wealth of information. Isotopes can reveal the charge state of
a peak, what types of elements may be contained in a particular molecule and can even reveal the elemental composition of a molecule through
accurate mass determination. We will also try to answer the question, "When should I use monoisotopic or average mass?" We will discuss how
changing resolution affects sensitivity and mass accuracy. We will also cover isotopic implications for mass spectrometer calibration and discuss
why centroiding programs cannot just be peak top pickers. Even though the subject is broad we have attempted to keep it very simple and have
included only those topics of isotopes that impact our lab on a daily basis. There are entire areas of study such as stable isotopes and isotopic
labeling that we have chosen not to address at this time, although they are very interesting and we may get back to them at some point.

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