《Mass Spectrometry：Principles and Applications》第三版

仪器资料 · 发表于 2019-3-22 14:44:35

《Mass Spectrometry：Principles and Applications》第三版
作者：Edmond de Hoffmann；Vincent Stroobant

《Mass Spectrometry：Principles and Applications》第三版- 一起下吧

Preface xi
Introduction 1
Principles 1
Diagram of a Mass Spectrometer 4
History 5
Ion Free Path 10
1 Ion Sources 15
1.1 Electron Ionization 15
1.2 Chemical Ionization 17
1.2.1 Proton transfer 19
1.2.2 Adduct formation 21
1.2.3 Charge-transfer chemical ionization 21
1.2.4 Reagent gas 22
1.2.5 Negative ion formation 25
1.2.6 Desorption chemical ionization 27
1.3 Field Ionization 28
1.4 Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry 29
1.5 Field Desorption 31
1.6 Plasma Desorption 32
1.7 Laser Desorption 33
1.8 Matrix-Assisted Laser Desorption Ionization 33
1.8.1 Principle of MALDI 33
1.8.2 Practical considerations 36
1.8.3 Fragmentations 39
1.8.4 Atmospheric pressure matrix-assisted laser desorption ionization 39
1.9 Thermospray 41
1.10 Atmospheric Pressure Ionization 42
1.11 Electrospray 43
1.11.1 Multiply charged ions 46
1.11.2 Electrochemistry and electric field as origins of multiply charged ions 48
1.11.3 Sensitivity to concentration 50
1.11.4 Limitation of ion current from the source by the electrochemical process 51
1.11.5 Practical considerations 54
1.12 Atmospheric Pressure Chemical Ionization 55
1.13 Atmospheric Pressure Photoionization 56
1.14 Atmospheric Pressure Secondary Ion Mass Spectrometry 61
1.14.1 Desorption electrospray ionization 61
1.14.2 Direct analysis in real time 62
1.15 Inorganic Ionization Sources 65
1.15.1 Thermal ionization source 65
1.15.2 Spark source 67
1.15.3 Glow discharge source 68
1.15.4 Inductively coupled plasma source 69
1.15.5 Practical considerations 71
1.16 Gas-Phase Ion-Molecule Reactions 72
1.17 Formation and Fragmentation of Ions: Basic Rules 76
1.17.1 Electron ionization and photoionization under vacuum 77
1.17.2 Ionization at low pressure or at atmospheric pressure 77
1.17.3 Proton transfer 77
1.17.4 Adduct formation 78
1.17.5 Formation of aggregates or clusters 79
1.17.6 Reactions at the interface between source and analyser 79
2 Mass Analysers 85
2.1 Quadrupole Analysers 88
2.1.1 Description 88
2.1.2 Equations of motion 91
2.1.3 Ion guide and collision cell 96
2.1.4 Spectrometers with several quadrupoles in tandem 98
2.2 Ion Trap Analysers 100
2.2.1 The 3D ion trap 100
2.2.2 The 2D ion trap 117
2.3 The Electrostatic Trap or ‘Orbitrap’ 122
2.4 Time-of-Flight Analysers 126
2.4.1 Linear time-of-flight mass spectrometer 126
2.4.2 Delayed pulsed extraction 129
2.4.3 Reflectrons 131
2.4.4 Tandem mass spectrometry with time-of-flight analyser 134
2.4.5 Orthogonal acceleration time-of-flight instruments 139
2.5 Magnetic and Electromagnetic Analysers 143
2.5.1 Action of the magnetic field 143
2.5.2 Electrostatic field 144
2.5.3 Dispersion and resolution 145
2.5.4 Practical considerations 146
2.5.5 Tandem mass spectrometry in electromagnetic analysers 149
2.6 Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry 157
2.6.1 General principle 157
2.6.2 Ion cyclotron resonance 159
2.6.3 Fourier transform mass spectrometry 159
2.6.4 MSn in ICR/FTMS instruments 164
2.7 Hybrid Instruments 164
2.7.1 Electromagnetic analysers coupled to quadrupoles or ion trap 165
2.7.2 Ion trap analyser combined with time-of-flight or ion cyclotron
resonance 166
2.7.3 Hybrids including time-of-flight with orthogonal acceleration 167
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