It has been 5 years since the fourth edition was completed. The fifth edition has
some significant organizational changes, as suggested by extensive surveys of
faculty and students who used the fourth edition in their classes and studies. The
major pedagogic features of the text remain. They have been enhanced by the
following changes for the fifth edition:
1. Every patient history has been reviewed and revised to reflect current
standards of care (as of 2016). The patient names have also been changed
to a first name and last initial. A key indicating the “old” names and
“new” names is available in the online supplement associated with the
text.
2. The Biochemical Comments associated with each chapter have been
updated, where appropriate, to allow students to experience where
current research efforts are headed.
3. The presentation of metabolism has been altered such that glycolysis is
now the first topic discussed, followed by the tricarboxylic acid cycle,
and then oxidative phosphorylation. The correlation between fourth
edition chapters and fifth edition chapters are as follows:
a. Chapters 1 through 18, no change
b. Section IV is now entitled “Carbohydrate Metabolism, Fuel
Oxidation, and the Generation of Adenosine Triphosphate” and
consists of Chapters 19 through 28.
i. Chapter 19 of the fifth edition (Basic Concepts in the Regulation
of Fuel Metabolism by Insulin, Glucagon, and Other Hormones)
is based on Chapter 26 of the fourth edition.
ii. Chapter 20 of the fifth edition (Cellular Bioenergetics:
Adenosine Triphosphate and O2) is based on Chapter 19 of the
fourth edition.
iii. Chapter 21 of the fifth edition (Digestion, Absorption, and
Transport of Carbohydrates) is based on Chapter 27 of the fourth
edition.
iv. Chapter 22 of the fifth edition (Generation of Adenosine
Triphosphate from Glucose, Fructose, and Galactose:
Glycolysis) is based on Chapter 22 of the fourth edition and also
contains parts of Chapter 29 of the fourth edition (Pathways of
Sugar Metabolism: Pentose Phosphate Pathway, Fructose, and
Galactose Metabolism).
v. Chapter 23 of the fifth edition (Tricarboxylic Acid Cycle) is
based on Chapter 20 of the fourth edition.
vi. Chapter 24 of the fifth edition (Oxidative Phosphorylation and
Mitochondrial Function) is based on Chapter 21 of the fourth
edition.
vii. Chapter 25 of the fifth edition (Oxygen Toxicity and Free-
Radical Injury) is based on Chapter 24 of the fourth edition.
viii. Chapter 26 of the fifth edition (Formation and Degradation of
Glycogen) is based on Chapter 28 of the fourth edition.
ix. Chapter 27 of the fifth edition (Pentose Phosphate Pathway and
the Synthesis of Glycosides, Lactose, Glycoproteins, and
Glycolipids) is based on Chapter 30 of the fourth edition, along
with a section (The Pentose Phosphate Pathway) of Chapter 29
of the fourth edition. This led to the deletion of old Chapter 29
from the Table of Contents of the fifth edition.
x. Chapter 28 of the fifth edition (Gluconeogenesis and
Maintenance of Blood Glucose Levels) is based on Chapter 31
of the fourth edition.
c. Section V (Lipid Metabolism) now consists of the following
chapters:
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