CE研究药物与蛋白的相互作用

仪器资料 · 发表于 2017-9-6 07:55:15

CE研究药物与蛋白的相互作用
Capillary electrophoresis is a well-established technique for the study of noncovalent
interactions. Various approaches exist and capillary electrophoresis-frontal analysis
provides an interesting alternative to the migration shift affinity capillary electrophoresis
methods and conventional methods. The present work reviews the principles on
which the frontal analysis method is founded. Advantages and limitations of capillary
electrophoresis frontal analysis in comparison with both conventional and other capillary
electrophoresis based methods for quantification of binding interactions are discussed.
Investigations utilizing capillary electrophoresis-frontal analysis have focused
on the interaction of drugs with plasma proteins. These studies, primarily addressing
the binding of drugs to human serum albumin, 1-acid glycoprotein, and lipoproteins
are reviewed together with some recent developments in capillary electrophoresisfrontal
analysis methodology.

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