Waters XevoG2QTof操作员概述和维护指南

仪器资料 · 发表于 2018-1-23 19:47:51

XevoG2QTof操作员概述和维护指南

目录
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x 目录
IntelliStart 射流系统 ...................................................................................................... 1-10
IntelliStart 射流系统物理布局 .................................................................................... 1-11
系统操作 ...................................................................................................................... 1-12
离子光学组件 ..................................................................................................................... 1-12
渗漏传感器 ......................................................................................................................... 1-13
真空系统 ............................................................................................................................ 1-13
2 质谱仪的操作准备 ................................................................................................................. 2-1
启动质谱仪 ........................................................................................................................... 2-2
检验仪器的准备状态 ...................................................................................................... 2-3
监视质谱仪 LED ............................................................................................................ 2-3
校正 ................................................................................................................................ 2-3
ACQUITY Xevo G2 QTof 系统的流速 .......................................................................... 2-3
准备 IntelliStart 射流系统 ................................................................................................ 2-4
安装样品瓶 ..................................................................................................................... 2-4
清除泵 ............................................................................................................................ 2-5
重新启动质谱仪 .................................................................................................................... 2-6
使质谱仪维持准备就绪状态 .................................................................................................. 2-6
紧急关闭质谱仪 .................................................................................................................... 2-6
3 配置 LockSpray 源 ............................................................................................................. 3-1
配置 LockSpray 源 ............................................................................................................ 3-2
配置 ESI 模式 ...................................................................................................................... 3-2
安装 ESI 探头 ................................................................................................................ 3-2
拆卸 ESI 探头 ................................................................................................................ 3-6
安装小口径毛细管选件 ......................................................................................................... 3-7
配置 APCI 模式 ................................................................................................................. 3-13
安装 APCI 探头 ........................................................................................................... 3-13
在源中安装电晕放电针 ................................................................................................. 3-17
从源上拆卸电晕放电针 ................................................................................................. 3-17
拆卸 APCI 探头 ........................................................................................................... 3-17
配置 ESCi 模式 ................................................................................................................. 3-18
优化 ESI 探头以便进行 ESCi 操作 .............................................................................. 3-18
在源中安装电晕放电针 ................................................................................................. 3-18
从源上拆卸电晕放电针 ................................................................................................. 3-18
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目录xi
4 配置 NanoLockSpray 源 ................................................................................................... 4-1
NanoLockSpray 源概览 ................................................................................................... 4-2
样品喷雾器 ..................................................................................................................... 4-3
Lock-spray 喷雾器 ......................................................................................................... 4-3
NanoFlow 气体供应 ...................................................................................................... 4-3
清除气体 ........................................................................................................................ 4-4
喷雾器平台调节器装置 ................................................................................................... 4-4
配置 NanoLockSpray 源 .................................................................................................. 4-4
选择源类型 ........................................................................................................................... 4-5
移入和移出喷雾器平台 ......................................................................................................... 4-5
调节喷雾器尖端位置 ............................................................................................................ 4-6
设置摄像头 ........................................................................................................................... 4-7
可选的玻璃毛细管喷雾器 ..................................................................................................... 4-8
安装反压气体管路 .......................................................................................................... 4-8
安装玻璃毛细管喷雾器 ................................................................................................... 4-9
安装并加载玻璃毛细管 ................................................................................................. 4-10
5 维护程序 ................................................................................................................................ 5-1
维护计划 .............................................................................................................................. 5-3
备件 ...................................................................................................................................... 5-4
使用 Connections Insight 排除故障 ............................................................................... 5-5
安全和处理 ........................................................................................................................... 5-6
准备仪器以便在源上工作 ..................................................................................................... 5-7
拆卸并重新安装源封闭 ......................................................................................................... 5-7
从仪器拆卸源封闭 .......................................................................................................... 5-7
将源封闭安装到仪器上 ................................................................................................. 5-10
安装和拆卸电晕放电针 ....................................................................................................... 5-11
在源中安装电晕放电针 ................................................................................................. 5-11
从源上拆卸电晕放电针 ................................................................................................. 5-13
操作源隔离阀 ..................................................................................................................... 5-14
拆卸 O 形圈和密封 ............................................................................................................. 5-17
清洁仪器容器 ..................................................................................................................... 5-17
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xii 目录
清空氮气排放阀瓶 .............................................................................................................. 5-18
检查 Varian 低真空泵油位 ............................................................................................... 5-20
向 Varian 低真空泵加油 ................................................................................................... 5-21
更换 Varian 低真空泵油和油雾过滤器 ............................................................................. 5-23
清空低真空泵的油 ........................................................................................................ 5-23
更换油雾过滤器 ............................................................................................................ 5-24
为泵重新加油 ............................................................................................................... 5-25
清洁源组件 ......................................................................................................................... 5-27
清洁采样锥孔装置 .............................................................................................................. 5-27
从源上拆下采样锥孔装置 ............................................................................................. 5-27
拆卸采样锥孔装置 ........................................................................................................ 5-29
清洗样品锥孔和锥孔气体喷嘴 ...................................................................................... 5-31
装配采样锥孔装置 ........................................................................................................ 5-33
将采样锥孔装置安装到源上 .......................................................................................... 5-34
清洗提取锥孔 ..................................................................................................................... 5-35
从源装置上拆下离子源装置 .......................................................................................... 5-35
从离子源拆卸提取锥孔 ................................................................................................. 5-37
清洗提取锥孔 ............................................................................................................... 5-38
将提取锥孔安装到离子源上 .......................................................................................... 5-40
在源装置上安装离子源装置 .......................................................................................... 5-40
清洗离子源装置 .................................................................................................................. 5-41
拆卸离子源模块 ............................................................................................................ 5-41
清洗离子源组件 ............................................................................................................ 5-48
装配离子源模块 ............................................................................................................ 5-50
清洗源六极器装置 .............................................................................................................. 5-51
从源装置上拆下离子源装置、固定离子源的法兰盘和六极器 ....................................... 5-51
清洗六极器装置 ............................................................................................................ 5-53
将六极器装置、固定离子源的 PEEK 法兰盘和离子源装置安装在源装置上 ................ 5-55
更换 ESI 探头尖和垫圈 ..................................................................................................... 5-57
拆卸 ESI 探头尖和垫圈 ................................................................................................ 5-57
安装 ESI 探头尖和垫圈 ................................................................................................ 5-59
更换 ESI 探头样品毛细管 .................................................................................................. 5-60
拆卸现有毛细管 ............................................................................................................ 5-60
安装新毛细管 ............................................................................................................... 5-64
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目录xiii
清洁 APCI 探头尖 ............................................................................................................. 5-67
更换 APCI 探头样品毛细管 ............................................................................................... 5-68
拆卸现有毛细管 ............................................................................................................ 5-68
安装新毛细管 ............................................................................................................... 5-70
更换参比探头毛细管􀐙LockSpray 源􀐚 .......................................................................... 5-73
拆卸现有毛细管 ............................................................................................................ 5-74
安装新毛细管 ............................................................................................................... 5-75
更换参比探头毛细管􀐙NanoLockSpray 源􀐚 ................................................................. 5-76
将参比探头从 NanoLockSpray 源上拆下 .................................................................... 5-76
安装新的 TaperTip 和毛细管 ...................................................................................... 5-78
清洁或更换电晕放电针 ....................................................................................................... 5-80
更换 APCI 探头加热器 ...................................................................................................... 5-81
拆卸 APCI 探头加热器 ................................................................................................ 5-81
安装新的 APCI 探头加热器 ......................................................................................... 5-82
更换离子源源加热器 .......................................................................................................... 5-84
更换 LockSpray 源装置密封 ........................................................................................... 5-87
拆卸探头调节器装置的探头和源封闭密封 .................................................................... 5-87
安装新的源封闭和探头调节器装置的探头密封 ............................................................. 5-89
更换质谱仪的空气过滤器 ................................................................................................... 5-91
更换前门内的空气过滤器 ............................................................................................. 5-91
更换仪器侧面的空气过滤器 .......................................................................................... 5-93
更换 IntelliStart 射流管 .................................................................................................. 5-94
拆卸 IntelliStart 射流管 .............................................................................................. 5-96
连接 IntelliStart 射流 LockSpray 系统的管路 ............................................................ 5-96
连接 NanoLockSpray 源的参比连接管路 .................................................................. 5-102
连接 IntelliStart 射流样品输送系统的管路 ............................................................... 5-106
A 安全忠告 .............................................................................................................................. A-1
警告符号 ............................................................................................................................. A-2
特定任务的危险警告 ...................................................................................................... A-2
特定警告 ........................................................................................................................ A-3
注意符号 ............................................................................................................................. A-4
适用于所有 Waters 仪器的警告 ......................................................................................... A-5
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xiv 目录
电气和搬运符号 ................................................................................................................... A-6
电气符号 ........................................................................................................................ A-6
搬运符号 ........................................................................................................................ A-7
B 外部连接 .............................................................................................................................. B-1
质谱仪外部接线和真空连接 ................................................................................................. B-2
连接 Varian 充油低真空泵 ................................................................................................ B-3
进行 Varian 充油低真空泵的电气连接 .......................................................................... B-6
连接 Edwards 无油低真空泵 ............................................................................................ B-7
进行 Edwards 无油低真空泵的电气连接 ....................................................................... B-9
连接氮气供应 .................................................................................................................... B-10
连接碰撞室气体供应 ......................................................................................................... B-11
连接氮气排放管路 ............................................................................................................. B-12
连接废液管 ........................................................................................................................ B-14
连接 EPC ......................................................................................................................... B-17
连接工作站􀐙没有 ACQUITY LC 的系统􀐚 .................................................................... B-18
连接以太网线缆􀐙带有 ACQUITY LC 的系统􀐚 ............................................................. B-19
输入/输出信号连接器 ........................................................................................................ B-19
信号连接 ...................................................................................................................... B-22
连接到电源 ........................................................................................................................ B-24
连接 NanoLockSpray 源摄像头 .................................................................................... B-24
安装摄像头驱动程序软件 ............................................................................................. B-25
C 结构材料和兼容溶剂 ............................................................................................................ C-1
防止污染 ............................................................................................................................. C-2
接触溶剂的物品 ................................................................................................................... C-3
用于制备流动相的溶剂 ........................................................................................................ C-4