LC–NMR–MS in drug discovery

仪器资料 · 发表于 2018-6-11 17:46:03

LC–NMR–MS in drug discovery

Nuclear magnetic resonance spectroscopy (NMR) is arguably the most
versatile analytical platform for complex mixture analysis. Specifically,
interfacing liquid chromatography with parallel NMR and mass
spectrometry (LC–NMR–MS) gives comprehensive structural data on
metabolites of novel drugs in development. Applications in natural product,
combinatorial chemistry and drug metabolism studies are reviewed.
Microcoil probes and capillary separation methods have enormous
potential. Recent innovations to improve NMR detection limits include
CryoFlowProbesTM and on-line solid-phase extraction (LC–SPE–NMR).
These state-of-the-art analytical platforms are widely applicable to
identifying novel candidate drugs from diverse complex mixtures within
a drug discovery strategy.

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