This fourth and probably final edition of Principles of Biochemical Toxicology has, like the
previous editions, evolved against the background of my involvement with the teaching of
toxicology on various courses at various levels and in various places.
The objective of the book has always been to form a sound introduction to the basic
principles of the subject from a biochemical and mechanistic viewpoint. It is a testament to the
vitality and progression of toxicology that the increasing sophistication, complexity, and
expansion of the subject mean that revision of at least parts of this book is essential every few
years. However, a book of this size cannot realistically cover all of the diverse aspects of
toxicology in equal depth and detail and include all the new developments that are occurring,
hence the extensive bibliography, which should be used to complement this text where more
detail or other examples are wanted.
This is probably the most extensive revision, because I changed to a part-time teaching
contract in order to do it. I hope that readers feel it has been worthwhile!
As previously, I have taken into account comments that have been made to me since the
third edition was published. I have added new examples to broaden the scope as well as
updated existing ones. I have also redone, and I hope improved, many of the diagrams as well
as adding many new ones.
Special thanks to Anna for all her help with the diagrams.
Again, special thanks to Cathy, particularly this time for her critical comments and
advice, the diagrams she has drawn or helped with, and, as always, for her patience, support,
and, indeed, forebearance when I could not see the light at the end of the tunnel.
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