Part I THE MOLECULAR DESIGN OF LIFE
1 Biochemistry: An Evolving Science 1
2 Protein Composition and Structure 27
3 Exploring Proteins and Proteomes 65
4 DNA, RNA, and the Flow of Genetic Information 105
5 Exploring Genes and Genomes 135
6 Exploring Evolution and Bioinformatics 169
7 Hemoglobin: Portrait of a Protein in Action 191
8 Enzymes: Basic Concepts and Kinetics 215
9 Catalytic Strategies 251
10 Regulatory Strategies 285
11 Carbohydrates 315
12 Lipids and Cell Membranes 341
13 Membrane Channels and Pumps 367
14 Signal-Transduction Pathways 397
Part II TRANSDUCING AND STORING ENERGY
15 Metabolism: Basic Concepts and Design 423
16 Glycolysis and Gluconeogenesis 449
17 The Citric Acid Cycle 495
18 Oxidative Phosphorylation 523
19 The Light Reactions of Photosynthesis 565
20 The Calvin Cycle and the Pentose Phosphate
Pathway 589
21 Glycogen Metabolism 617
22 Fatty Acid Metabolism 643
23 Protein Turnover and Amino Acid Catabolism 681
Part III SYNTHESIZING THE MOLECULES OF LIFE
24 The Biosynthesis of Amino Acids 713
25 Nucleotide Biosynthesis 743
26 The Biosynthesis of Membrane Lipids and
Steroids 767
27 The Integration of Metabolism 801
28 DNA Replication, Repair, and Recombination 827
29 RNA Synthesis and Processing 859
30 Protein Synthesis 893
31 The Control of Gene Expression in Prokaryotes 925
32 The Control of Gene Expression in Eukaryotes 941
Part IV RESPONDING TO ENVIRONMENTAL
CHANGES
33 Sensory Systems 961
34 The Immune System 981
35 Molecular Motors 1011
36 Drug Development 1033