Liquid Chromatography– Mass Spectrometry Third Edition

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INTRODUCTION
Ch. 1 Liquid chromatography and sample pretreatment . . . . . . . . . . . . . . . . . . 3
Ch. 2 Mass spectrometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
TECHNOLOGY
Ch. 3 Strategies in LC–MS interfacing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
Ch. 4 History of LC–MS interfaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Ch. 5 Interfaces for atmospheric-pressure ionization . . . . . . . . . . . . . . . . . . . 105
Ch. 6 Atmospheric-pressure ionization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
APPLICATIONS: SMALL MOLECULES
Ch. 7 LC–MS analysis of pesticides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Ch. 8 Environmental applications of LC–MS . . . . . . . . . . . . . . . . . . . . . . . . 215
Ch. 9 LC–MS in drug discovery and development . . . . . . . . . . . . . . . . . . . . 233
Ch. 10 LC–MS in drug metabolism studies . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
Ch. 11 Quantitative bioanalysis using LC–MS . . . . . . . . . . . . . . . . . . . . . . . . 289
Ch. 12 Clinical applications of LC–MS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Ch. 13 LC–MS analysis of steroids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Ch. 14 LC–MS in food safety analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
Ch. 15 LC–MS analysis of plant phenols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 413
APPLICATIONS: BIOMOLECULES
Ch. 16 LC–MS analysis of proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 441
Ch. 17 LC–MS analysis of peptides / Enabling technologies . . . . . . . . . . . . . 463
Ch. 18 LC–MS in proteomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 493
Ch. 19 LC–MS for identification of post-translational modifications . . . . . . . 523
Ch. 20 LC–MS analysis of oligosaccharides . . . . . . . . . . . . . . . . . . . . . . . . . . 545
Ch. 21 LC–MS analysis of lipids and phospholipids . . . . . . . . . . . . . . . . . . . . 565
Ch. 22 LC–MS analysis of nucleic acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583