LC-MS在药物代谢组学中应用的综述

仪器资料 · 发表于 2018-7-8 22:24:19

LC-MS在药物代谢组学中应用的综述
Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating
signals for many pathophysiological events. Currently, most widely used techniques for
identifying xenobiotic metabolites and metabolic pathways are empirical and largely based
on in vitro incubation assays and in vivo radiotracing experiments. Recent work in our lab
has shown that LC-MS-based metabolomic techniques are useful tools for xenobiotic
metabolism research since multivariate data analysis in metabolomics can significantly
rationalize the processes of xenobiotic metabolite identification and metabolic pathway
analysis. In this review, the technological elements of LC-MS-based metabolomics for constructing
high-quality datasets and conducting comprehensive data analysis are examined.
Four novel approaches of using LC-MS-based metabolomic techniques in xenobiotic
metabolism research are proposed and illustrated by case studies and proof-of-concept
experiments, and the perspective on their application is further discussed.

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